Improvements in Behavioral Symptoms following Antibiotic Therapy in a 14-Year-Old Male with Autism
A recent article published in the Case Reports of Psychiatry showed how a 14 year old boy with autism had great improvement in his behaviors following antibiotic therapy. He was being treated for a suspected unrelated issue, but showed marked improvement in anxiety and self-injurious behavior with a course of metronidazole for a gastrointestinal infection. I have written and spoken about this trend now for many years. When you read the article (via the link provided) it is quite clear that this boys behavior’s in part are directly correlated with his poor gut function. Although, it wasn’t mentioned in the article, but my suspicion is this boy likely had elevated levels of a toxin called HPHPA.
HPHPA called 3-(3-hydroxyphenyl)-3-hydroxypropionic acid is an abnormal metabolite of clostridia bacteria species. It specifically interferes with a converting enzyme for dopamine which can lead to imbalances of neurotransmitters in the brain that contribute to psychological problems seen in autism, as well as schizophrenia. It has been recognized for years that clostridia bacteria are problematic and can lead to adverse behavior including psychosis, aggression, self-injury and violent outbursts in extreme situations. This is why it is imperative for every parent or caregiver of a loved one on the autism-spectrum, or an individual with mental health issues that involve mood instability, depression, aggression, volatile behavior, etc. to do an Organic Acid Test from Great Plains Laboratory. It is the OAT that has the specific HPHPA marker specific for clostridia. Another marker indicative of clostridia as well called 4-creosol and can contribute to many of the same behavior problems as HPHPA is also analyzed via the OAT.
If you are needing assistance in having the Organic Acid Test performed you can contact my office. I am available for consultations on the data provided by this important test.
Also, there are two websites which provide access to this test as well – www.AutismActionPlan.com and via their respective Lab Ordering sections.